Question:
Eating lots of candy licorice can it be harmful and raise blood pressure?
ngreenga53
2006-06-16 19:54:26 UTC
Was told candy licorice can be harmful to your health there is a ingredient in licorice that can cause side effects.
Four answers:
anonymous
2006-06-16 20:08:13 UTC
Licorice (Glycyrrhiza glabra) is a plant that grows wild in parts of Europe and Asia. One of the active components of licorice, glycyrrhizin, gives real licorice candy its sweet taste. As a medicinal herb, the root of the licorice plant has been used to treat ulcers, arthritis, cough, and infections such as the common cold or bronchitis.



Unfortunately, though, licorice root can be quite toxic. When large amounts of licorice root are ingested over an extended period of time, it can lead to high blood pressure, headache, lethargy, and loss of potassium in the urine that can lead to irregular heart rhythm and extreme weakness. To give you some sense of how much licorice it takes, in one experiment volunteers ate 100 to 200 grams of licorice twists (10 to 20 pieces) every day; after one month the participants began to experience the negative side effects described. A man who ate 700 grams (70 pieces of the twists) of licorice in nine days required a four-day hospitalization.



Licorice is found in some unexpected places. Tobacco products, for example, including cigarettes, cigars, pipes, and chewing tobacco all contain licorice; commercial cough syrups and cough drops also contain licorice. Some herbal cough syrups contain as much as 0.5 grams of licorice per serving.



For medicinal purposes today, licorice can be processed to remove the glychyrrhizin the component responsible for the negative side effects. The result is called deglycyrrhizinated licorice or DGL.



The licorice that you crave, though, may actually be anise flavoring found in "licorice" candy often sold in the United States. Unlike the authentic licorice candy sold in Europe, what tastes like licorice in America may actually be anise oil. Also unlike genuine licorice, anise does not cause the same negative side effects, including high blood pressure. Therefore, with American "licorice" candy, you can have the great taste without the harmful results.
anonymous
2006-06-17 03:12:49 UTC
Yes it seems so. Large doses of glycyrrhizinic acid and glycyrrhetinic acid in liquorice extract can lead to hypokalemia and serious increases in blood pressure, a syndrome known as Apparent Mineralocorticoid Excess. These side effects stem from the inhibition of the enzyme 11β-hydroxysteroid dehydrogenase (type 2) and subsequent increase in activity of cortisol on the kidney. 11β-hydroxysteroid dehydrogenase normally inactivates cortisol in the kidney, thus licorice's inactivation of this enzyme makes the concentration of cortisol appear to increase. Cortisol acts at the same receptor as the hormone aldosterone in the kidney, thus the effects mimic aldosterone excess, although aldosterone remains low or normal during licorice overdose. Cortisol does not actually increase either, but its activity in the kidney does, due to the disabling of this enzyme. To decrease the chances of these serious side effects, deglycyrrhizinated licorice (DGL) preparations are available.



Licorice affects the body's endocrine system. It can lower the amount of serum testosterone, but whether it affects the amount of free testosterone is unclear. A PubMed search for licorice AND testosterone will provide additional information. I would suggest trying the DGL preparation. On the other hand, it is effective as a cough remedy.
anonymous
2006-06-17 02:57:20 UTC
I was told black licorice was good for you.
anonymous
2006-06-17 02:58:23 UTC
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This content was originally posted on Y! Answers, a Q&A website that shut down in 2021.
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